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Inborn Errors Pyruvate Metabolism
Posted on July 24, 2011 |
Hereditary disorders of pyruvate metabolism. They are difficult to diagnose and describe because pyruvate is a key intermediate in glycolysis, gluconeogenesis, and the tricarboxylic acid cycle. Some inherited metabolic disorders may alter pyruvate metabolism indirectly. Disorders in pyruvate metabolism appear to lead to deficiencies in neurotransmitter synthesis and, consequently, to nervous system disorders.
Inappropriate Secretion Thyroid Stimulating Hormone
Posted on July 24, 2011 |
Inappropriate secretion of anterior pituitary gland hormones. The most common hormones involved in over-secretion are SOMATOTROPIN (which may cause ACROMEGALY) and PROLACTIN (which results in HYPERPROLACTINEMIA). THYROTROPIN; luteinizing hormone (LH); CORTICOTROPIN; and FOLLICLE STIMULATING HORMONE may also be secreted at inappropriate levels. Hypersecretion syndromes are frequently associated with the presence of a pituitary ADENOMA (see also PITUITARY NEOPLASMS).
Inbred MRL lpr Mouse
Posted on July 24, 2011 |
A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
Inclusion Body, Sporadic Myositis
Posted on July 24, 2011 |
Progressive myopathies characterized by the presence of inclusion bodies on muscle biopsy. Sporadic and hereditary forms have been described. The sporadic form is an acquired, adult-onset inflammatory vacuolar myopathy affecting proximal and distal muscles. Familial forms usually begin in childhood and lack inflammatory changes. Both forms feature intracytoplasmic and intranuclear inclusions in muscle tissue. (Adams et al., Principles of Neurology, 6th ed, pp1409-10)
IGF Type 1 alpha Subunit Receptor
Posted on July 24, 2011 |
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precusor protein. The beta subunit contains an intrisic tyrosine kinase domain. EC 2.7.11.-.
In Hospital Mortality
Posted on July 24, 2011 |
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Impulsive, Janz Petit Mal
Posted on July 24, 2011 |
A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)
Impedance, Transthoracic Plethysmography
Posted on July 24, 2011 |
A type of impedance plethysmography in which bioelectrical impedance is measured between electrodes positioned around the neck and around the lower thorax. It is used principally to calculate stroke volume and cardiac volume, but it is also related to myocardial contractility, thoracic fluid content, and circulation to the extremities.
Infectious Feline Peritonitis Virus
Posted on July 24, 2011 |
A species of CORONAVIRUS infecting cats of all ages and commonly found in catteries and zoos. Cats are often found carrying the virus but only a small proportion develop disease. Feline coronavirus and Feline infectious peritonitis virus (FIPV) are virtually the same virus in genetic and antigenetic terms, and are morphologically indistinguishable. Since they only differ in their disease potential (with FIPV causing a more serious illness), they are considered biotypes of each other. (From Hoskins, JD. Update on Feline Coronavirus Disease. http://maxshouse.com.FIP%20Update.htm (April 3, 2001))
IGF-Binding Protein 2
Posted on July 24, 2011 |
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at the cellular level.